Scientific

Visual Processing & Eye Movement Journal Club

Anca Velisar will be presening her own recently published paper: Velisar et al., in press. “Dual threshold neural closed loop deep brain stimulation in Parkinson disease patients,” Brain Stimulation

Photo of Kyoung-Min Lee

Interocular interactions across time and in torsion

Abstract: The two eyes are yoked, and yet the visual inputs are disparate in space and time. How the brain works on these disparities to achieve unitary perception is one of the fundamental questions in neuroscience. In this talk, I will first discuss temporal disparity that presumably underlies normal and clinical perceptual phenomena, such as the Pulfrich effect and visual symptoms in patients with optic neuritis. Recent experiments in my lab demonstrated neural signatures of interocular inhibition in visual evoked potentials when asynchrony was introduced in binocular visual stimulation. Second, I will focus on torsional disparity between the eyes. While studied much less than other types of spatial disparity, it is of substantial scientific and technological significance: 1)      Given the importance of orientation tuning in the visual cortices, torsional disparity leading to orientation mismatch between the two retinae compli- cates the correspondence problem in binocular summation and suppression. 2)      It poses one of the most challenging issues in virtual reality technology, such as head-mounted displays (HMD), since torsion differs between the two eyes in vergence, due to the binocular extension of Listing’s law. Investigations in my lab have shown that this indeed is a significant factor in neurologic side effects of HMD. Ways to understand and study the impact of torsion and/or temporal disparities on perception and oculomotor kinematics will be discussed.   Host: John Brabyn

Photo of Dragan Ahmetovic

Accessing digital documents with mathematical content for people with visual impairments

 Abstract:  Accessing scientific content within digital documents is often challenging for people with visual impairments. Text information can be easily accessed by the means of assistive tools such as refreshable braille displays or screen readers. However, mathematical formulae or graphs are difficult to translate into an accessible form while preserving the expressiveness of the original format. Providing accessible content is a burden left to document authors, which requires substantial time and effort. Document authors are also frequently unaware of the need for document accessibility, and they may not have the required know-how to create accessible documents. Thus, scientific content is rarely provided in an accessible format, which creates a barrier for access to STEM education and employment for people with visual impairments.   At laboratory “S. Polin” of the University of Turin, Italy, our research focuses on assistive technologies to enable the access to digital documents with scientific content for people with visual impairments. I will present two of our most recent works: Axessibility is a LaTeX package for generating PDF documents in which mathematical formulae are accessible to people with visual impairments using braille displays or screen readers, without requiring the author to add accessible content manually. AudioFunctions.web is a web-based system that enables blind people to explore mathematical function graphs, using sonification, earcons and speech synthesis to convey the overall shape of the function graph, its key points of interest, is accurate quantitative information at any given point. 

Photo of Audrey Wong-Kee-You

The Development of Memory and Visual Attention

Abstract: Infants’ and children’s brains undergo a large amount of change throughout development. These changes lead to improvements in visual and cognitive abilities – such as visual functions and the ability to pay attention or encode events to memory. During this Brown Bag, I will present the developmental research I completed during my graduate studies, focusing on my Master’s thesis and PhD dissertation work. For my Master’s thesis, I used the Visual Expectation Paradigm (Haith et al., 1988) to study memory in infants. Infants’ anticipatory eye movements were measured on 2 consecutive days. On day 1, infants were trained to form expectations and make anticipatory eye movements based on the predictable color and spatial location of visual stimuli. On day 2, they were presented with either the same stimuli, or different stimuli which varied by color or location. I will present the results and discuss how visual expectation processes are related to mechanisms of memory in infancy. My PhD dissertation examined spatial attention-modulated surround suppression during development. In adults, previous research has demonstrated that a suppressive field is present surrounding a spatial location of attentional focus. This results from top-down attention promoting the processing of relevant stimuli and inhibiting surrounding distractors (Tsotsos, 1995; Hopf et al., 2006). The goal of my dissertation was to examine how this phenomenon manifests in children and adolescents. I will present data proposing that top-down attentional processes are likely still maturing until approximately 12 years of age. https://ski.org/users/audrey-wong-kee-you

Photo of Marcus Missal

Anticipation and its troubles

Abstract: A short reaction time is necessary for survival in a rapidly changing environment, and anticipatory actions are often initiated before the occurrence of an expected event. In the oculomotor domain, it has been shown that anticipatory eye movements are based on an internal representation of elapsed time. The timing of eye movements has been studied in the Rhesus monkey at the behavioral and electrophysiological levels (Badler and Heinen 2006; Heinen et al. 2005; Janssen and Shadlen 2005; de Hemptinne et al. 2007), making it the perfect model to study the biological bases of movement timing in general. In this talk, I will present electrophysiological evidence from my work supporting the hypothesis that the Supple-mentary Eye Fields play a specific role in the planning of anticipatory eye movements (Missal and Heinen 2004; de Hemptinne et al. 2008). Moreover, the influence of NMDA receptor antagonists (ketamine and memantine) on the perception of elapsed time and anticipatory responses will be presented (Ameqrane et al. 2015; Brûlé et al. in prep). I will conclude by discussing the complex relationship between temporal preparation and impulsivity in humans and particularly in Major Depression Disorder (Hsu et al. submitted). http://www.insosci.eu/team/louvain-la-neuve/prof-dr-marcus-missal/

dr

Topographic population codes in primate V1

Abstract: What is the nature of the neural code in primate primary visual cortex (V1)? Two key properties of primate V1 are relevant to this question. First, V1 representations are widely distributed. Because receptive fields of neighboring V1 neurons largely overlap, the cortical point image (the V1 area that encompasses all the neurons whose receptive fields contain a given point in the visual field) spreads over multiple square millimeters and contains millions of neurons. Second, V1 is topographically organized. It contains a large-scale (multiple mm) homeomorphic map of the contralateral visual field (‘retinotopic map’), and finer scale (sub-mm) semi-periodic topographic maps of stimulus features such as edge orientation (columnar ‘orientation map’). The distributed and topographic nature of V1’s representations raises the possibility that in some visual tasks, downstream areas that decode V1 signals in order to mediate perception could combine V1 signals at the relevant topographic scale—e.g., at the scale of orientation columns. If this were the case, then the fundamental unit of information would be individual columns rather than single neurons, and to account for the subject’s behavior in a perceptual task, it would be necessary and sufficient to consider the summed activity of the thousands of neurons within each column. In this presentation, I will discuss several studies that begin to test this topographic-code hypothesis by using optical methods to measure and perturb neural population responses in V1 of behaving macaques.

preeti_v

Stereopsis in the periphery

Abstract: We have shown previously that individuals with dense central scotomas due to macular degeneration have better eye-hand coordination when they have coarse stereopsis. Here we investigate the hypothesis that this degree of stereopsis is determined by the scale of receptive fields at the eccentricity with intact binocular function, i.e., at the eccentricity with input from corresponding locations in the two eyes. To test this hypothesis, we measured binocular fusion and stereopsis in the periphery as a function of eccentricity in normal controls and show that these are indeed consistent with estimates of human population receptive fields in putative disparity encoding regions of the cortex.   https://ski.org/users/preeti-verghese