Publication Types
Abstract
OBJECTIVE: To examine the relationship between the cause or severity of hypotension and the development of severe ROP (sROP) (≥stage 3 or stage 2 with plus disease in zone I or II).
STUDY DESIGN: Infants (<28 weeks' gestation, n=242) were observed for hypotension and treated with a standardized hypotension-treatment protocol. was classified as resulting from one of the following causes: (1) culture-positive infection or necrotizing enterocolitis; (2) patent ductus arteriosus ligation; (3) "idiopathic" (no cause identified other than prematurity), being either dopamine responsive resistant. cortisol levels measured infants dopamine-resistant hypotension. eye examinations performed until retinopathy prematurity resolved vasculature matured. multivariable logistic regression analysis to determine relationship between severity srop. results: overall, 66% developed (41% 25% resistant). srop in 19% infants. only significantly related srop. hypotension, had low serum (≤10 μg dl). cortisol, presence associated accounted when included statistical models, known risk factors, such immature no longer srop. conclusion: has greatest magnitude association srop. free pmc article. pmcid: pmc3676698 < p>
