Child Development Informs Pediatric Eye Disease: Marshall Parks Lecture 2023




In children, the brain and eyes undergo astonishing development beginning in the first trimester and ending well after birth. The mature brain, for example, looks and functions very differently than the developing one. For example, the premature brain, with its blood supply partially derived from the germinal matrix, gradually adopts its blood supply from the more mature large cerebral vessels. A damaging event prenatally can have a different clinical appearance than one that occurs several years after birth. While conventional disease models in ophthalmology consider the time of onset of a