Our research interests include brain plasticity in sensory processing associated with amblyopia (lazy eye) and strabismus (misaligned eyes). We also study visual development of infants and children in clinical populations.
Tabs
Journal Articles
. (2017). Latent Binocular Interactions in Cortical Area V1 of Human Amblyopia. Journal Of Vision, 17(10), 758-758. http://doi.org/10.1167/17.10.758 (Original work published 2017)
. (2017). Cortical sources of vernier acuity in the human visual system: an EEG source-imaging study. Journal Of Vision, 17(6). (Original work published 2017)
. (2016). Degraded attentional modulation of cortical neural populations in strabismic amblyopia. Journal Of Vision, 16(3), 1–16.
. (2016). Degraded attentional modulation of cortical neural populations in strabismic amblyopia. Journal Of Vision, 16, 16.
. (2015). Cortical sources of vernier acuity: an EEG-source imaging study. Journal Of Vision, 15, 1004.
. (2015). Visuocortical bilirubin-induced neurological dysfunction. Semin Fetal Neonatal Med, 20(1), 37-41.
. (2014). Visuocortical function in infants with a history of neonatal jaundice. Invest Ophthalmol Vis Sci, 55(10), 6443-9.
. (2014). Acuity-independent effects of visual deprivation on human visual cortex. Proc Natl Acad Sci U S A, 111(30), E3120-8.
. (2012). Piecing together: infants' neural responses to face and object structure. J Vis, 12(13), 1-14.
. (2012). Effect of Grade I and II intraventricular hemorrhage on visuocortical function in very low birth weight infants. Seeing Perceiving, 25(2), 143-54.
. (2012). Spatial Contrast Sensitivity Loss In Children With Cortical Visual Impairment. Invest Ophthalmol Vis Sci, 53(12), 7730-4.
. (2011). Visual Cortical Function in Very Low Birth Weight Infants without Retinal or Cerebral Pathology. Invest Ophthalmol Vis Sci, 52(12), 9091-8.
. (2010). Connecting the dots: how local structure affects global integration in infants. J Cogn Neurosci, 22(7), 1557-69.
. (2010). Effects of monocular visual deprivation on parameters of GLuRs in visual cortex in developing kittens. Sichuan Da Xue Xue Bao Yi Xue Ban, 41(1), 111-3.
. (2010). Quantitative fiber tracking of the optic radiation is correlated with visual-evoked potential amplitude in preterm infants. Ajnr Am J Neuroradiol, 31(8), 1424-9.
. (2009). Evidence for visual compromise in preverbal children with orbital vascular birthmarks. Am J Ophthalmol, 147(4), 679-682.
. (2009). Spatio-temporal tuning of coherent motion evoked responses in 4-6 month old infants and adults. Vision Research, 49(20), 2509-17.
. (2008). Abnormalities of coherent motion processing in strabismic amblyopia: Visual-evoked potential measurements. Journal Of Vision, 8(4), 1-12.
. (2007). Validation study of VEP vernier acuity in normal-vision and amblyopic adults. Invest Ophthalmol Vis Sci, 48(9), 4070-8.
. (2006). Sweep visual evoked potential grating acuity thresholds paradoxically improve in low-luminance conditions in children with cortical visual impairment. Invest Ophthalmol Vis Sci, 47(7), 3220-4.
. (2006). Study on crossed and uncrossed disparity evoked potential of dynamic random dot stereogram. Zhonghua Yan Ke Za Zhi, 42(10), 878-82.
. (2005). Development of sensitivity to texture and contour information in the human infant. J Cogn Neurosci, 17(4), 569-79.
. (2005). Experience-expectant development of contour integration mechanisms in human visual cortex. J Vis, 5(2), 116-30.
. (2004). Normal vernier acuity in infants with delayed visual maturation. Am J Ophthalmol, 138(1), 140-2.
. (2003). Stereopsis of the patients after cataract extraction and intraocular lens implantation. Sichuan Da Xue Xue Bao Yi Xue Ban, 34(3), 539-40.
. (2003). Development of the spatial organization and dynamics of lateral interactions in the human visual system. Journal Of Neuroscience, 23(25), 8630-40.
. (2002). An epidemiological study on senile cataract in urban and rural areas of Chengdu. Hua Xi Yi Ke Da Xue Xue Bao, 33(2), 256-8.
. (2001). Orbital lacrimal gland tumor malignant mixed with the sclera, the optic nerve invasion case. Chinese Journal Of Ocular Fundus Disease, 17(2), 158.
. (2001). The observed effect of surgery on congenital superior oblique palsy. Optometry And Ophthalmology Journal, 3, 203-204.
. (2000). After retinal detachment with yeast-like infection case. Chinese Journal Of Ocular Fundus Disease, 16(2), 147.
. (2000). The detection of disparity evoked potentials in anisometropes. Zhonghua Yan Ke Za Zhi, 36(4), 278-81.
. (1999). The analysis of disparity evoked potentials in children and adults. Chinese Journal Of Strabismus & Pediatric Ophthalmology, 9(4), 161-65.
. (1998). The analysis of disparity evoked potentials in ametropia. Chinese Journal Of Ocular Fundus Disease, 14(4), 225-29.
. (1995). The analysis of static disparity evoked potentials by different disparity stimuli in normal vision subjects. Chinese Journal Of Ocular Fundus Disease, 11(3), 155-58.
. (1995). The analysis of disparity evoked potentials by a new form of static random-dot stereograms. Yan Ke Xue Bao, 11(1), 48-52.
. (1995). Development and detection of stereopsis. Chinese Journal Of Strabismus & Pediatric Ophthalmology, 3(3), 141-44.
. (1992). Binocular disparity in VEP relate to stereopsis. Chinese Journal Of Ocular Fundus Disease, 8(1), 10-13.
Verghese Lab
Our laboratory studies the mechanisms of healthy vision and action, as well as the basis of attention and visual adaptation in clinical populations.
The Role of Selective Visual Attention in Amblyopic Suppression
Individuals with strabismus are confronted with double vision, their brain has to choose to attend to one image and ignore or suppress the other. It has been commonly suggested that a constant suppression on the non-preferred eye in strabismus is responsible for the development...
Alleviating interocular suppression by high-attention demand training in amblyopia
The goal of this project is to test a hypothesis that whether or not training patients to pay more attention to the input from the amblyopic eye can overcome interocular suppression to treat amblyopia.
Fellow Eye Deficits in Strabismic Amblyopia
Fellow eye abnormalities have been reported in a number of psychophysical and VEP studies. The goal of this project is to characterize the fellow eye deficits.
Grouping and Perception in Different Types of Amblyopia
This project was to measure the neural correlates of grouping and perception in different types of amblyopia. We found that strabismus generates significant abnormalities at both early and later stages of cortical processing and, importantly, that these abnormalities are...
Texture Segmentation in Human Infants and Adults with Amblyopia
This project study the neural mechanisms of texture and motion based segmentation as basic inputs to object processing. This project used frequency-domain non-linear analysis of high-density EEG recordings in human infants. We also used fMRI-...
Motion Integration in infants and amblyopia
This project studies the integration of local estimates of motion direction and orientation into global patterns. Integration mechanisms were studied in human infants, normal adults and in adults with amblyopia.
Neonatal Jaundice and Vision Loss
High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown.
Visual Cortical Function in Very Low Birth Weight Infants
Preterm infants are at high risk of visual and neural developmental deficits. We used swept parameter visual evoked potential (sVEP) to determine whether premature birth alters visual cortical function.
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